Common variants in TMPRSS6 are associated with iron status and erythrocyte volume

Beben Benyamin; Manuel A.R. Ferreira; Gonneke Willemsen; Scott Gordon; Rita P.S. Middelberg; Brian P. McEvoy; Jouke Jan Hottenga; Anjali K. Henders; Megan J. Campbell; Leanne Wallace; Ian H. Frazer; Andrew C. Heath; Eco J.C. De Geus; Dale R. Nyholt; Peter M. Visscher; Brenda W. Penninx; Dorret I. Boomsma; Nicholas G. Martin; Grant W. Montgomery; John B. Whitfield

doi:10.1038/ng.456

Common variants in TMPRSS6 are associated with iron status and erythrocyte volume

Beben Benyamin^*
, Manuel A.R. Ferreira
, Gonneke Willemsen
, Scott Gordon
, Rita P.S. Middelberg
, Brian P. McEvoy
, Jouke Jan Hottenga
, Anjali K. Henders
, Megan J. Campbell
, Leanne Wallace
, Ian H. Frazer
, Andrew C. Heath
, Eco J.C. De Geus
, Dale R. Nyholt
, Peter M. Visscher
, Brenda W. Penninx
, Dorret I. Boomsma
, Nicholas G. Martin
, Grant W. Montgomery
, John B. Whitfield

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

218 Citations (Scopus)

Abstract

We report a genome-wide association study to iron status. We identify an association of SNPs in TPMRSS6 to serum iron (rs855791, combined P = 1.5 × 10 20), transferrin saturation (combined P = 2.2 × 10 23) and erythrocyte mean cell volume (MCV, combined P = 1.1 × 10 10). We also find suggestive evidence of association with blood hemoglobin levels (combined P = 5.3 × 10 7). These findings demonstrate the involvement of TMPRSS6 in control of iron homeostasis and in normal erythropoiesis.

Original language	English
Pages (from-to)	1173-1175
Number of pages	3
Journal	Nature Genetics
Volume	41
Issue number	11
DOIs	https://doi.org/10.1038/ng.456
Publication status	Published - 11 Oct 2009
Externally published	Yes

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Benyamin, B., Ferreira, M. A. R., Willemsen, G., Gordon, S., Middelberg, R. P. S., McEvoy, B. P., Hottenga, J. J., Henders, A. K., Campbell, M. J., Wallace, L., Frazer, I. H., Heath, A. C., De Geus, E. J. C., Nyholt, D. R., Visscher, P. M., Penninx, B. W., Boomsma, D. I., Martin, N. G., Montgomery, G. W., & Whitfield, J. B. (2009). Common variants in TMPRSS6 are associated with iron status and erythrocyte volume. Nature Genetics, 41(11), 1173-1175. https://doi.org/10.1038/ng.456

@article{b7253a24bb8045d8bf3fb0e24cbd1f8f,

title = "Common variants in TMPRSS6 are associated with iron status and erythrocyte volume",

abstract = "We report a genome-wide association study to iron status. We identify an association of SNPs in TPMRSS6 to serum iron (rs855791, combined P = 1.5 × 10 20), transferrin saturation (combined P = 2.2 × 10 23) and erythrocyte mean cell volume (MCV, combined P = 1.1 × 10 10). We also find suggestive evidence of association with blood hemoglobin levels (combined P = 5.3 × 10 7). These findings demonstrate the involvement of TMPRSS6 in control of iron homeostasis and in normal erythropoiesis.",

author = "Beben Benyamin and Ferreira, \{Manuel A.R.\} and Gonneke Willemsen and Scott Gordon and Middelberg, \{Rita P.S.\} and McEvoy, \{Brian P.\} and Hottenga, \{Jouke Jan\} and Henders, \{Anjali K.\} and Campbell, \{Megan J.\} and Leanne Wallace and Frazer, \{Ian H.\} and Heath, \{Andrew C.\} and \{De Geus\}, \{Eco J.C.\} and Nyholt, \{Dale R.\} and Visscher, \{Peter M.\} and Penninx, \{Brenda W.\} and Boomsma, \{Dorret I.\} and Martin, \{Nicholas G.\} and Montgomery, \{Grant W.\} and Whitfield, \{John B.\}",

year = "2009",

month = oct,

day = "11",

doi = "10.1038/ng.456",

language = "English",

volume = "41",

pages = "1173--1175",

journal = "Nature Genetics",

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number = "11",

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Benyamin, B, Ferreira, MAR, Willemsen, G, Gordon, S, Middelberg, RPS, McEvoy, BP, Hottenga, JJ, Henders, AK, Campbell, MJ, Wallace, L, Frazer, IH, Heath, AC, De Geus, EJC, Nyholt, DR, Visscher, PM, Penninx, BW, Boomsma, DI, Martin, NG, Montgomery, GW & Whitfield, JB 2009, 'Common variants in TMPRSS6 are associated with iron status and erythrocyte volume', Nature Genetics, vol. 41, no. 11, pp. 1173-1175. https://doi.org/10.1038/ng.456

TY - JOUR

T1 - Common variants in TMPRSS6 are associated with iron status and erythrocyte volume

AU - Benyamin, Beben

AU - Ferreira, Manuel A.R.

AU - Willemsen, Gonneke

AU - Gordon, Scott

AU - Middelberg, Rita P.S.

AU - McEvoy, Brian P.

AU - Hottenga, Jouke Jan

AU - Henders, Anjali K.

AU - Campbell, Megan J.

AU - Wallace, Leanne

AU - Frazer, Ian H.

AU - Heath, Andrew C.

AU - De Geus, Eco J.C.

AU - Nyholt, Dale R.

AU - Visscher, Peter M.

AU - Penninx, Brenda W.

AU - Boomsma, Dorret I.

AU - Martin, Nicholas G.

AU - Montgomery, Grant W.

AU - Whitfield, John B.

PY - 2009/10/11

Y1 - 2009/10/11

N2 - We report a genome-wide association study to iron status. We identify an association of SNPs in TPMRSS6 to serum iron (rs855791, combined P = 1.5 × 10 20), transferrin saturation (combined P = 2.2 × 10 23) and erythrocyte mean cell volume (MCV, combined P = 1.1 × 10 10). We also find suggestive evidence of association with blood hemoglobin levels (combined P = 5.3 × 10 7). These findings demonstrate the involvement of TMPRSS6 in control of iron homeostasis and in normal erythropoiesis.

AB - We report a genome-wide association study to iron status. We identify an association of SNPs in TPMRSS6 to serum iron (rs855791, combined P = 1.5 × 10 20), transferrin saturation (combined P = 2.2 × 10 23) and erythrocyte mean cell volume (MCV, combined P = 1.1 × 10 10). We also find suggestive evidence of association with blood hemoglobin levels (combined P = 5.3 × 10 7). These findings demonstrate the involvement of TMPRSS6 in control of iron homeostasis and in normal erythropoiesis.

UR - https://www.scopus.com/pages/publications/70350628958

U2 - 10.1038/ng.456

DO - 10.1038/ng.456

M3 - Article

C2 - 19820699

AN - SCOPUS:70350628958

SN - 1061-4036

VL - 41

SP - 1173

EP - 1175

JO - Nature Genetics

JF - Nature Genetics

IS - 11

ER -

Common variants in TMPRSS6 are associated with iron status and erythrocyte volume

Abstract

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