Common variants at 6q22 and 17q21 are associated with intracranial volume

M. Arfan Ikram; Myriam Fornage; Albert V. Smith; Sudha Seshadri; Reinhold Schmidt; Stéphanie Debette; Henri A. Vrooman; Sigurdur Sigurdsson; Stefan Ropele; H. Rob Taal; Dennis O. Mook-Kanamori; Laura H. Coker; W. T. Longstreth; Wiro J. Niessen; Anita L. Destefano; Alexa Beiser; Alex P. Zijdenbos; Maksim Struchalin; Clifford R. Jack; Fernando Rivadeneira; Andre G. Uitterlinden; David S. Knopman; Anna Liisa Hartikainen; Craig E. Pennell; Elisabeth Thiering; Eric A.P. Steegers; Hakon Hakonarson; Joachim Heinrich; Lyle J. Palmer; Marjo Riitta Jarvelin; Mark I. Mccarthy; Struan F.A. Grant; Beate St Pourcain; Nicholas J. Timpson; George Davey Smith; Ulla Sovio; Mike A. Nalls; Rhoda Au; Albert Hofman; Haukur Gudnason; Aad Van Der Lugt; Tamara B. Harris; William M. Meeks; Meike W. Vernooij; Mark A. Van Buchem; Diane Catellier; Vincent W.V. Jaddoe; Vilmundur Gudnason; B. Gwen Windham; Philip A. Wolf; Cornelia M. Van Duijn; Thomas H. Mosley; Helena Schmidt; Lenore J. Launer; Monique M.B. Breteler; Charles Decarli; Linda S. Adair; Wei Ang; Mustafa Atalay; Toos Van Beijsterveldt; Nienke Bergen; Kelly Benke; Diane Berry; Lachlan Coin; Oliver S.P. Davis; Paul Elliott; Claudia Flexeder; Tim Frayling; Romy Gaillard; Maria Groen-Blokhuis; Liang Kee Goh; Claire M.A. Haworth; Dexter Hadley; Johannes Hedebrand; Anke Hinney; Joel N. Hirschhorn; John W. Holloway; Claus Holst; Jouke Jan Hottenga; Momoko Horikoshi; Ville Huikari; Elina Hypponen; Tuomas O. Kilpeläinen; Mirna Kirin; Matthew Kowgier; Hanna Maaria Lakka; Leslie A. Lange; Debbie A. Lawlor; Terho Lehtimäki; Alex Lewin; Cecilia Lindgren; Virpi Lindi; Reedik Maggi; Julie Marsh; Christel Middeldorp; Iona Millwood; Jeffrey C. Murray; Michel Nivard; Ellen Aagaard Nohr; Ioanna Ntalla; Emily Oken; Kalliope Panoutsopoulou; Jennifer Pararajasingham; Alina Rodriguez; Rany M. Salem; Sylvain Sebert; Niina Siitonen; David P. Strachan; Yik Ying Teo; Beatriz Valcárcel; Gonneke Willemsen; Eleftheria Zeggini; Dorret I. Boomsma; Cyrus Cooper; Matthew Gillman; Berthold Hocher; Timo A. Lakka; Karen L. Mohlke; George V. Dedoussis; Ken K. Ong; Ewan R. Pearson; Thomas S. Price; Chris Power; Olli T. Raitakari; Seang Mei Saw; Andre Scherag; Olli Simell; Thorkild I.A. Sørensen; James F. Wilson

doi:10.1038/ng.2245

Common variants at 6q22 and 17q21 are associated with intracranial volume

M. Arfan Ikram^*
, Myriam Fornage
, Albert V. Smith
, Sudha Seshadri
, Reinhold Schmidt
, Stéphanie Debette
, Henri A. Vrooman
, Sigurdur Sigurdsson
, Stefan Ropele
, H. Rob Taal
, Dennis O. Mook-Kanamori
, Laura H. Coker
, W. T. Longstreth
, Wiro J. Niessen
, Anita L. Destefano
, Alexa Beiser
, Alex P. Zijdenbos
, Maksim Struchalin
, Clifford R. Jack
, Fernando Rivadeneira

Andre G. Uitterlinden, David S. Knopman, Anna Liisa Hartikainen, Craig E. Pennell, Elisabeth Thiering, Eric A.P. Steegers, Hakon Hakonarson, Joachim Heinrich, Lyle J. Palmer, Marjo Riitta Jarvelin, Mark I. Mccarthy, Struan F.A. Grant, Beate St Pourcain, Nicholas J. Timpson, George Davey Smith, Ulla Sovio, Mike A. Nalls, Rhoda Au, Albert Hofman, Haukur Gudnason, Aad Van Der Lugt, Tamara B. Harris, William M. Meeks, Meike W. Vernooij, Mark A. Van Buchem, Diane Catellier, Vincent W.V. Jaddoe, Vilmundur Gudnason, B. Gwen Windham, Philip A. Wolf, Cornelia M. Van Duijn, Thomas H. Mosley, Helena Schmidt, Lenore J. Launer, Monique M.B. Breteler, Charles Decarli, Linda S. Adair, Wei Ang, Mustafa Atalay, Toos Van Beijsterveldt, Nienke Bergen, Kelly Benke, Diane Berry, Lachlan Coin, Oliver S.P. Davis, Paul Elliott, Claudia Flexeder, Tim Frayling, Romy Gaillard, Maria Groen-Blokhuis, Liang Kee Goh, Claire M.A. Haworth, Dexter Hadley, Johannes Hedebrand, Anke Hinney, Joel N. Hirschhorn, John W. Holloway, Claus Holst, Jouke Jan Hottenga, Momoko Horikoshi, Ville Huikari, Elina Hypponen, Tuomas O. Kilpeläinen, Mirna Kirin, Matthew Kowgier, Hanna Maaria Lakka, Leslie A. Lange, Debbie A. Lawlor, Terho Lehtimäki, Alex Lewin, Cecilia Lindgren, Virpi Lindi, Reedik Maggi, Julie Marsh, Christel Middeldorp, Iona Millwood, Jeffrey C. Murray, Michel Nivard, Ellen Aagaard Nohr, Ioanna Ntalla, Emily Oken, Kalliope Panoutsopoulou, Jennifer Pararajasingham, Alina Rodriguez, Rany M. Salem, Sylvain Sebert, Niina Siitonen, David P. Strachan, Yik Ying Teo, Beatriz Valcárcel, Gonneke Willemsen, Eleftheria Zeggini, Dorret I. Boomsma, Cyrus Cooper, Matthew Gillman, Berthold Hocher, Timo A. Lakka, Karen L. Mohlke, George V. Dedoussis, Ken K. Ong, Ewan R. Pearson, Thomas S. Price, Chris Power, Olli T. Raitakari, Seang Mei Saw, Andre Scherag, Olli Simell, Thorkild I.A. Sørensen, James F. Wilson

^*Corresponding author for this work

Erasmus University Rotterdam
Netherlands Consortium for Healthy Aging
University of North Carolina at Chapel Hill
University of Texas Health Science Center at Houston
Icelandic Heart Association
University of Iceland
Boston University
National Heart Lung and Blood Institute’s and Boston University’s Framingham Heart Study
Medical University of Graz
Vrije Universiteit Amsterdam
Institut national de la santé et de la recherche médicale
Weill Cornell Medicine-Qatar
Wake Forest University
University of Washington
Delft University of Technology
University of Montreal
Mayo Clinic Rochester, MN
University of Oulu
University of Western Australia
Helmholtz Zentrum München - German Research Center for Environmental Health
Children's Hospital of Philadelphia
University of Pennsylvania
University of Toronto
Medical Research Council
National Institutes of Health
University of Oxford
University of Bristol
London School of Hygiene and Tropical Medicine
University of Mississippi
Leiden University
University of Eastern Finland
University College London
German Center for Neurodegenerative Diseases
University of California at Davis
King's College London
University of Exeter
National University of Singapore
University of Duisburg-Essen
Boston Children's Hospital
Harvard University
Broad Institute
University of Southampton
University of Copenhagen
Imperial College London
University of Edinburgh
Tampere University
University of Tartu
Wellcome Trust Sanger Institute
Harokopio University
University of Iowa
St. George's University of London
University of Turku
MRC Lifecourse Epidemiology Unit
University of Potsdam
German Centre for Cardiovascular Research
University of Cambridge
University of Dundee
Mid Sweden University
Singapore National Eye Center

Research output: Contribution to journal › Article › peer-review

100 Citations (Scopus)

Abstract

During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 × 10 ^-8) for brain volume. In contrast, intracranial volume was significantly associated with two loci: rs4273712 (P = 3.4 × 10 ^-11), a known height-associated locus on chromosome 6q22, and rs9915547 (P = 1.5 × 10 ^-12), localized to the inversion on chromosome 17q21. We replicated the associations of these loci with intracranial volume in a separate sample of 1,752 elderly persons (P = 1.1 × 10 ^-3 for 6q22 and 1.2 × 10 ^-3 for 17q21). Furthermore, we also found suggestive associations of the 17q21 locus with head circumference in 10,768 children (mean age of 14.5 months). Our data identify two loci associated with head size, with the inversion at 17q21 also likely to be involved in attaining maximal brain size.

Original language	English
Pages (from-to)	539-544
Number of pages	6
Journal	Nature Genetics
Volume	44
Issue number	5
DOIs	https://doi.org/10.1038/ng.2245
Publication status	Published - 15 Apr 2012
Externally published	Yes

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10.1038/ng.2245

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Ikram, M. A., Fornage, M., Smith, A. V., Seshadri, S., Schmidt, R., Debette, S., Vrooman, H. A., Sigurdsson, S., Ropele, S., Taal, H. R., Mook-Kanamori, D. O., Coker, L. H., Longstreth, W. T., Niessen, W. J., Destefano, A. L., Beiser, A., Zijdenbos, A. P., Struchalin, M., Jack, C. R., ... Wilson, J. F. (2012). Common variants at 6q22 and 17q21 are associated with intracranial volume. Nature Genetics, 44(5), 539-544. https://doi.org/10.1038/ng.2245

@article{48861bb803834ab2b410080c75cfa1a5,

title = "Common variants at 6q22 and 17q21 are associated with intracranial volume",

abstract = "During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 × 10 -8) for brain volume. In contrast, intracranial volume was significantly associated with two loci: rs4273712 (P = 3.4 × 10 -11), a known height-associated locus on chromosome 6q22, and rs9915547 (P = 1.5 × 10 -12), localized to the inversion on chromosome 17q21. We replicated the associations of these loci with intracranial volume in a separate sample of 1,752 elderly persons (P = 1.1 × 10 -3 for 6q22 and 1.2 × 10 -3 for 17q21). Furthermore, we also found suggestive associations of the 17q21 locus with head circumference in 10,768 children (mean age of 14.5 months). Our data identify two loci associated with head size, with the inversion at 17q21 also likely to be involved in attaining maximal brain size.",

author = "Ikram, \{M. Arfan\} and Myriam Fornage and Smith, \{Albert V.\} and Sudha Seshadri and Reinhold Schmidt and St{\'e}phanie Debette and Vrooman, \{Henri A.\} and Sigurdur Sigurdsson and Stefan Ropele and Taal, \{H. Rob\} and Mook-Kanamori, \{Dennis O.\} and Coker, \{Laura H.\} and Longstreth, \{W. T.\} and Niessen, \{Wiro J.\} and Destefano, \{Anita L.\} and Alexa Beiser and Zijdenbos, \{Alex P.\} and Maksim Struchalin and Jack, \{Clifford R.\} and Fernando Rivadeneira and Uitterlinden, \{Andre G.\} and Knopman, \{David S.\} and Hartikainen, \{Anna Liisa\} and Pennell, \{Craig E.\} and Elisabeth Thiering and Steegers, \{Eric A.P.\} and Hakon Hakonarson and Joachim Heinrich and Palmer, \{Lyle J.\} and Jarvelin, \{Marjo Riitta\} and Mccarthy, \{Mark I.\} and Grant, \{Struan F.A.\} and Pourcain, \{Beate St\} and Timpson, \{Nicholas J.\} and Smith, \{George Davey\} and Ulla Sovio and Nalls, \{Mike A.\} and Rhoda Au and Albert Hofman and Haukur Gudnason and \{Van Der Lugt\}, Aad and Harris, \{Tamara B.\} and Meeks, \{William M.\} and Vernooij, \{Meike W.\} and \{Van Buchem\}, \{Mark A.\} and Diane Catellier and Jaddoe, \{Vincent W.V.\} and Vilmundur Gudnason and Windham, \{B. Gwen\} and Wolf, \{Philip A.\} and \{Van Duijn\}, \{Cornelia M.\} and Mosley, \{Thomas H.\} and Helena Schmidt and Launer, \{Lenore J.\} and Breteler, \{Monique M.B.\} and Charles Decarli and Adair, \{Linda S.\} and Wei Ang and Mustafa Atalay and \{Van Beijsterveldt\}, Toos and Nienke Bergen and Kelly Benke and Diane Berry and Lachlan Coin and Davis, \{Oliver S.P.\} and Paul Elliott and Claudia Flexeder and Tim Frayling and Romy Gaillard and Maria Groen-Blokhuis and Goh, \{Liang Kee\} and Haworth, \{Claire M.A.\} and Dexter Hadley and Johannes Hedebrand and Anke Hinney and Hirschhorn, \{Joel N.\} and Holloway, \{John W.\} and Claus Holst and \{Jan Hottenga\}, Jouke and Momoko Horikoshi and Ville Huikari and Elina Hypponen and Kilpel{\"a}inen, \{Tuomas O.\} and Mirna Kirin and Matthew Kowgier and Lakka, \{Hanna Maaria\} and Lange, \{Leslie A.\} and Lawlor, \{Debbie A.\} and Terho Lehtim{\"a}ki and Alex Lewin and Cecilia Lindgren and Virpi Lindi and Reedik Maggi and Julie Marsh and Christel Middeldorp and Iona Millwood and Murray, \{Jeffrey C.\} and Michel Nivard and Nohr, \{Ellen Aagaard\} and Ioanna Ntalla and Emily Oken and Kalliope Panoutsopoulou and Jennifer Pararajasingham and Alina Rodriguez and Salem, \{Rany M.\} and Sylvain Sebert and Niina Siitonen and Strachan, \{David P.\} and Teo, \{Yik Ying\} and Beatriz Valc{\'a}rcel and Gonneke Willemsen and Eleftheria Zeggini and Boomsma, \{Dorret I.\} and Cyrus Cooper and Matthew Gillman and Berthold Hocher and Lakka, \{Timo A.\} and Mohlke, \{Karen L.\} and Dedoussis, \{George V.\} and Ong, \{Ken K.\} and Pearson, \{Ewan R.\} and Price, \{Thomas S.\} and Chris Power and Raitakari, \{Olli T.\} and Saw, \{Seang Mei\} and Andre Scherag and Olli Simell and S{\o}rensen, \{Thorkild I.A.\} and Wilson, \{James F.\}",

year = "2012",

month = apr,

day = "15",

doi = "10.1038/ng.2245",

language = "English",

volume = "44",

pages = "539--544",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "5",

}

Ikram, MA, Fornage, M, Smith, AV, Seshadri, S, Schmidt, R, Debette, S, Vrooman, HA, Sigurdsson, S, Ropele, S, Taal, HR, Mook-Kanamori, DO, Coker, LH, Longstreth, WT, Niessen, WJ, Destefano, AL, Beiser, A, Zijdenbos, AP, Struchalin, M, Jack, CR, Rivadeneira, F, Uitterlinden, AG, Knopman, DS, Hartikainen, AL, Pennell, CE, Thiering, E, Steegers, EAP, Hakonarson, H, Heinrich, J, Palmer, LJ, Jarvelin, MR, Mccarthy, MI, Grant, SFA, Pourcain, BS, Timpson, NJ, Smith, GD, Sovio, U, Nalls, MA, Au, R, Hofman, A, Gudnason, H, Van Der Lugt, A, Harris, TB, Meeks, WM, Vernooij, MW, Van Buchem, MA, Catellier, D, Jaddoe, VWV, Gudnason, V, Windham, BG, Wolf, PA, Van Duijn, CM, Mosley, TH, Schmidt, H, Launer, LJ, Breteler, MMB, Decarli, C, Adair, LS, Ang, W, Atalay, M, Van Beijsterveldt, T, Bergen, N, Benke, K, Berry, D, Coin, L, Davis, OSP, Elliott, P, Flexeder, C, Frayling, T, Gaillard, R, Groen-Blokhuis, M, Goh, LK, Haworth, CMA, Hadley, D, Hedebrand, J, Hinney, A, Hirschhorn, JN, Holloway, JW, Holst, C, Jan Hottenga, J, Horikoshi, M, Huikari, V, Hypponen, E, Kilpeläinen, TO, Kirin, M, Kowgier, M, Lakka, HM, Lange, LA, Lawlor, DA, Lehtimäki, T, Lewin, A, Lindgren, C, Lindi, V, Maggi, R, Marsh, J, Middeldorp, C, Millwood, I, Murray, JC, Nivard, M, Nohr, EA, Ntalla, I, Oken, E, Panoutsopoulou, K, Pararajasingham, J, Rodriguez, A, Salem, RM, Sebert, S, Siitonen, N, Strachan, DP, Teo, YY, Valcárcel, B, Willemsen, G, Zeggini, E, Boomsma, DI, Cooper, C, Gillman, M, Hocher, B, Lakka, TA, Mohlke, KL, Dedoussis, GV, Ong, KK, Pearson, ER, Price, TS, Power, C, Raitakari, OT, Saw, SM, Scherag, A, Simell, O, Sørensen, TIA & Wilson, JF 2012, 'Common variants at 6q22 and 17q21 are associated with intracranial volume', Nature Genetics, vol. 44, no. 5, pp. 539-544. https://doi.org/10.1038/ng.2245

TY - JOUR

T1 - Common variants at 6q22 and 17q21 are associated with intracranial volume

AU - Ikram, M. Arfan

AU - Fornage, Myriam

AU - Smith, Albert V.

AU - Seshadri, Sudha

AU - Schmidt, Reinhold

AU - Debette, Stéphanie

AU - Vrooman, Henri A.

AU - Sigurdsson, Sigurdur

AU - Ropele, Stefan

AU - Taal, H. Rob

AU - Mook-Kanamori, Dennis O.

AU - Coker, Laura H.

AU - Longstreth, W. T.

AU - Niessen, Wiro J.

AU - Destefano, Anita L.

AU - Beiser, Alexa

AU - Zijdenbos, Alex P.

AU - Struchalin, Maksim

AU - Jack, Clifford R.

AU - Rivadeneira, Fernando

AU - Uitterlinden, Andre G.

AU - Knopman, David S.

AU - Hartikainen, Anna Liisa

AU - Pennell, Craig E.

AU - Thiering, Elisabeth

AU - Steegers, Eric A.P.

AU - Hakonarson, Hakon

AU - Heinrich, Joachim

AU - Palmer, Lyle J.

AU - Jarvelin, Marjo Riitta

AU - Mccarthy, Mark I.

AU - Grant, Struan F.A.

AU - Pourcain, Beate St

AU - Timpson, Nicholas J.

AU - Smith, George Davey

AU - Sovio, Ulla

AU - Nalls, Mike A.

AU - Au, Rhoda

AU - Hofman, Albert

AU - Gudnason, Haukur

AU - Van Der Lugt, Aad

AU - Harris, Tamara B.

AU - Meeks, William M.

AU - Vernooij, Meike W.

AU - Van Buchem, Mark A.

AU - Catellier, Diane

AU - Jaddoe, Vincent W.V.

AU - Gudnason, Vilmundur

AU - Windham, B. Gwen

AU - Wolf, Philip A.

AU - Van Duijn, Cornelia M.

AU - Mosley, Thomas H.

AU - Schmidt, Helena

AU - Launer, Lenore J.

AU - Breteler, Monique M.B.

AU - Decarli, Charles

AU - Adair, Linda S.

AU - Ang, Wei

AU - Atalay, Mustafa

AU - Van Beijsterveldt, Toos

AU - Bergen, Nienke

AU - Benke, Kelly

AU - Berry, Diane

AU - Coin, Lachlan

AU - Davis, Oliver S.P.

AU - Elliott, Paul

AU - Flexeder, Claudia

AU - Frayling, Tim

AU - Gaillard, Romy

AU - Groen-Blokhuis, Maria

AU - Goh, Liang Kee

AU - Haworth, Claire M.A.

AU - Hadley, Dexter

AU - Hedebrand, Johannes

AU - Hinney, Anke

AU - Hirschhorn, Joel N.

AU - Holloway, John W.

AU - Holst, Claus

AU - Jan Hottenga, Jouke

AU - Horikoshi, Momoko

AU - Huikari, Ville

AU - Hypponen, Elina

AU - Kilpeläinen, Tuomas O.

AU - Kirin, Mirna

AU - Kowgier, Matthew

AU - Lakka, Hanna Maaria

AU - Lange, Leslie A.

AU - Lawlor, Debbie A.

AU - Lehtimäki, Terho

AU - Lewin, Alex

AU - Lindgren, Cecilia

AU - Lindi, Virpi

AU - Maggi, Reedik

AU - Marsh, Julie

AU - Middeldorp, Christel

AU - Millwood, Iona

AU - Murray, Jeffrey C.

AU - Nivard, Michel

AU - Nohr, Ellen Aagaard

AU - Ntalla, Ioanna

AU - Oken, Emily

AU - Panoutsopoulou, Kalliope

AU - Pararajasingham, Jennifer

AU - Rodriguez, Alina

AU - Salem, Rany M.

AU - Sebert, Sylvain

AU - Siitonen, Niina

AU - Strachan, David P.

AU - Teo, Yik Ying

AU - Valcárcel, Beatriz

AU - Willemsen, Gonneke

AU - Zeggini, Eleftheria

AU - Boomsma, Dorret I.

AU - Cooper, Cyrus

AU - Gillman, Matthew

AU - Hocher, Berthold

AU - Lakka, Timo A.

AU - Mohlke, Karen L.

AU - Dedoussis, George V.

AU - Ong, Ken K.

AU - Pearson, Ewan R.

AU - Price, Thomas S.

AU - Power, Chris

AU - Raitakari, Olli T.

AU - Saw, Seang Mei

AU - Scherag, Andre

AU - Simell, Olli

AU - Sørensen, Thorkild I.A.

AU - Wilson, James F.

PY - 2012/4/15

Y1 - 2012/4/15

N2 - During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 × 10 -8) for brain volume. In contrast, intracranial volume was significantly associated with two loci: rs4273712 (P = 3.4 × 10 -11), a known height-associated locus on chromosome 6q22, and rs9915547 (P = 1.5 × 10 -12), localized to the inversion on chromosome 17q21. We replicated the associations of these loci with intracranial volume in a separate sample of 1,752 elderly persons (P = 1.1 × 10 -3 for 6q22 and 1.2 × 10 -3 for 17q21). Furthermore, we also found suggestive associations of the 17q21 locus with head circumference in 10,768 children (mean age of 14.5 months). Our data identify two loci associated with head size, with the inversion at 17q21 also likely to be involved in attaining maximal brain size.

AB - During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 × 10 -8) for brain volume. In contrast, intracranial volume was significantly associated with two loci: rs4273712 (P = 3.4 × 10 -11), a known height-associated locus on chromosome 6q22, and rs9915547 (P = 1.5 × 10 -12), localized to the inversion on chromosome 17q21. We replicated the associations of these loci with intracranial volume in a separate sample of 1,752 elderly persons (P = 1.1 × 10 -3 for 6q22 and 1.2 × 10 -3 for 17q21). Furthermore, we also found suggestive associations of the 17q21 locus with head circumference in 10,768 children (mean age of 14.5 months). Our data identify two loci associated with head size, with the inversion at 17q21 also likely to be involved in attaining maximal brain size.

UR - https://www.scopus.com/pages/publications/84860342407

U2 - 10.1038/ng.2245

DO - 10.1038/ng.2245

M3 - Article

C2 - 22504418

AN - SCOPUS:84860342407

SN - 1061-4036

VL - 44

SP - 539

EP - 544

JO - Nature Genetics

JF - Nature Genetics

IS - 5

ER -

Common variants at 6q22 and 17q21 are associated with intracranial volume

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