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Chain of Thought Strategy for Smaller LLMs for Medical Reasoning

  • Hurmat Ali Shah
  • , Mowafa Househ*
  • *Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

This paper investigates the application of Chain of Thought (CoT) reasoning to enhance the performance of smaller language models in medical question-answering tasks. By leveraging CoT prompting strategies, we aim to improve model accuracy and interpretability, especially in resource-constrained settings. Using the PubMedQA dataset, we demonstrate how CoT helps smaller models break down complex medical queries into sequential steps, enabling more structured reasoning. While these models still face challenges in handling highly specialized medical content, CoT significantly improves their viability for healthcare applications. Our findings suggest that further optimization through methods like retrieval-augmented generation could further close the performance gap between smaller and larger models.

Original languageEnglish
Title of host publicationIntelligent Health Systems - From Technology to Data and Knowledge, Proceedings of MIE 2025
EditorsElisavet Andrikopoulou, Parisis Gallos, Theodoros N. Arvanitis, Rosalynn Austin, Arriel Benis, Ronald Cornet, Panagiotis Chatzistergos, Alexander Dejaco, Linda Dusseljee-Peute, Alaa Mohasseb, Pantelis Natsiavas, Haythem Nakkas, Philip Scott
PublisherIOS Press BV
Pages783-787
Number of pages5
ISBN (Electronic)9781643685960
DOIs
Publication statusPublished - 15 May 2025
Event35th Medical Informatics Europe Conference, MIE 2025 - Glasgow, United Kingdom
Duration: 19 May 202521 May 2025

Publication series

NameStudies in Health Technology and Informatics
Volume327
ISSN (Print)0926-9630
ISSN (Electronic)1879-8365

Conference

Conference35th Medical Informatics Europe Conference, MIE 2025
Country/TerritoryUnited Kingdom
CityGlasgow
Period19/05/2521/05/25

Keywords

  • Chain of Thought
  • Large Language Models
  • Medical Reasoning

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