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BRET-BASED CORONAVIRUS MPRO PROTEASE SENSOR AND USES THEREOF
Anupriya M Geethakumari
(Inventor)
,
Kabir Hassan Biswas
(Inventor)
HBKU College of Health & Life Sciences
Biological and Biomedical Sciences
Qatar Foundation for Education, Science, and Community Development
Research output
:
Patent
Overview
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Keyphrases
Transfer Based
100%
Coronavirus
100%
Protease Sensor
100%
Bioluminescence Resonance Energy Transfer
100%
Mpro Inhibitors
100%
Living Cells
60%
GC376
60%
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
60%
Functional Genomics
40%
Sequence Variation
40%
Pharmacological Agents
40%
Genomic Applications
40%
FlipGFP
40%
Co-expression
20%
Host Cell
20%
In Vitro Assay
20%
SARS-CoV-2 Main Protease
20%
NanoLuc
20%
Sequence Preference
20%
Molecular Crowding
20%
Inhibitory Potential
20%
Genetically Encoded
20%
MNeonGreen
20%
Proteolytic Activity
20%
Autocleavage
20%
Single-molecule Fluorescence Resonance Energy Transfer (smFRET)
20%
Temporal Activity
20%
Dose-dependent
20%
Anti-SARS-CoV-2 Agents
20%
Immunology and Microbiology
Coronavirinae
100%
Severe Acute Respiratory Syndrome Coronavirus 2
100%
Energy Transfer
100%
Bioluminescence
100%
Proteinase
100%
Protease
100%
In Vitro
40%
Amino Terminal Sequence
20%
Protein Degradation
20%
Host Cell
20%
Molecular Crowding
20%
Replication
20%
Biochemistry, Genetics and Molecular Biology
SARS Coronavirus
100%
Energy Transfer
100%
Coronavirinae
100%
Protease
100%
Bioluminescence
100%
Functional Genomics
40%
Drug Development
40%
N-Terminus
20%
Protein Catabolism
20%
Molecular Crowding
20%
Fluorescence Resonance Energy Transfer
20%
Chemistry
Fluorescence Resonance Energy Transfer
100%
Bioluminescence
100%
Pharmacologic Agent
40%
proteolytic
20%
Material Science
Bioluminescence
100%
Resonance Fluorescence
25%