Atypical cadherins Celsr1-3 and planar cell polarity in vertebrates

  • Fadel Tissir*
  • , André M. Goffinet
  • *Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

21 Citations (Scopus)

Abstract

Cadherin EGF LAG seven-pass G-type receptors 1, 2, and 3 (Celsr1-3) form a family of three atypical cadherins with multiple functions in epithelia and in the nervous system. During the past decade, evidence has accumulated for important and distinct roles of Celsr1-3 in planar cell polarity (PCP) during the development of the brain and some other organs. Although Celsr function in PCP is conserved from flies to mammals, other functions may be more distantly related, with Celsr working only with one or a subset of the classical core PCP partners. Here, we review the literature on Celsr, focusing on PCP and particularly on brain development.

Original languageEnglish
Title of host publicationThe Molecular Biology of Cadherins
PublisherElsevier B.V.
Pages193-214
Number of pages22
ISBN (Print)9780123943118
DOIs
Publication statusPublished - 2013
Externally publishedYes

Publication series

NameProgress in Molecular Biology and Translational Science
Volume116
ISSN (Print)1877-1173

Keywords

  • Axon guidance
  • Cell polarity
  • Celsr
  • Flamingo
  • Neural tube closure
  • Neuronal migration

Fingerprint

Dive into the research topics of 'Atypical cadherins Celsr1-3 and planar cell polarity in vertebrates'. Together they form a unique fingerprint.

Cite this