A Perspective on Evaluating Life Stage Differences in Drug Dosages for Drug Labeling and Instructions

Tianshu Gu; Guiying Wang; Edwin J.C. van den Oord; Emanuel Goldman; Chengyuan Yang; Ning Xie; Lan Yao; Cong Yi Wang; Monica Jablonski; Kunal Ray; Fengxia Liu; Wensen Pan; Gonzalo Flores; Lotfi Aleya; Xia Meng; Yan Jiao; Minghui Li; Yongjun Wang; Weikuan Gu

doi:10.1208/s12248-024-00964-0

A Perspective on Evaluating Life Stage Differences in Drug Dosages for Drug Labeling and Instructions

Tianshu Gu
, Guiying Wang
, Edwin J.C. van den Oord
, Emanuel Goldman
, Chengyuan Yang
, Ning Xie
, Lan Yao
, Cong Yi Wang
, Monica Jablonski
, Kunal Ray
, Fengxia Liu
, Wensen Pan
, Gonzalo Flores
, Lotfi Aleya
, Xia Meng
, Yan Jiao
, Minghui Li^*
, Yongjun Wang^*
, Weikuan Gu^*

^*Corresponding author for this work

University of Tennessee Health Science Center
Capital Medical University
Hebei Medical University
Virginia Commonwealth University
Rutgers - The State University of New Jersey, New Brunswick
University of Louisville
Harbin Medical University
Center for Biomedical Research
Huazhong University of Science and Technology
Ramkrishna Mission Vivekananda Education & Research Institute
Benemerita Universidad Autonoma de Puebla
Université Bourgogne Franche-Comté
Department of Veterans Affairs

Research output: Contribution to journal › Article › peer-review

Abstract

Drug labeling and instructions provide essential information for patients regarding the usage of drugs. Instructions for the dosage of drug usage are critical for the effectiveness of the drug and the safety of patients. The dosage of many drugs varies depending on the patient's age. However, as our understanding of human biology deepens, we believe that these instructions need to be modified to incorporate different life stages. This is because human biology and metabolism differ significantly among different life stages, and their responses to drugs also vary. Additionally, the same age of different persons may fall into different life stages. Therefore, our group from multiple institutes and countries proposes a reexamination of whether incorporating life stages in all or any drug instructions will greatly enhance drug efficiency and patients' health.

Original language	English
Article number	95
Number of pages	8
Journal	AAPS Journal
Volume	26
Issue number	5
DOIs	https://doi.org/10.1208/s12248-024-00964-0
Publication status	Published - 20 Aug 2024
Externally published	Yes

Keywords

Disease
Drug labeling
Life stage
Metabolism
Puberty

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10.1208/s12248-024-00964-0

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Gu, T., Wang, G., van den Oord, E. J. C., Goldman, E., Yang, C., Xie, N., Yao, L., Wang, C. Y., Jablonski, M., Ray, K., Liu, F., Pan, W., Flores, G., Aleya, L., Meng, X., Jiao, Y., Li, M., Wang, Y., & Gu, W. (2024). A Perspective on Evaluating Life Stage Differences in Drug Dosages for Drug Labeling and Instructions. AAPS Journal, 26(5), Article 95. https://doi.org/10.1208/s12248-024-00964-0

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abstract = "Drug labeling and instructions provide essential information for patients regarding the usage of drugs. Instructions for the dosage of drug usage are critical for the effectiveness of the drug and the safety of patients. The dosage of many drugs varies depending on the patient's age. However, as our understanding of human biology deepens, we believe that these instructions need to be modified to incorporate different life stages. This is because human biology and metabolism differ significantly among different life stages, and their responses to drugs also vary. Additionally, the same age of different persons may fall into different life stages. Therefore, our group from multiple institutes and countries proposes a reexamination of whether incorporating life stages in all or any drug instructions will greatly enhance drug efficiency and patients' health.",

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AU - Goldman, Emanuel

AU - Yang, Chengyuan

AU - Xie, Ning

AU - Yao, Lan

AU - Wang, Cong Yi

AU - Jablonski, Monica

AU - Ray, Kunal

AU - Liu, Fengxia

AU - Pan, Wensen

AU - Flores, Gonzalo

AU - Aleya, Lotfi

AU - Meng, Xia

AU - Jiao, Yan

AU - Li, Minghui

AU - Wang, Yongjun

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PY - 2024/8/20

Y1 - 2024/8/20

N2 - Drug labeling and instructions provide essential information for patients regarding the usage of drugs. Instructions for the dosage of drug usage are critical for the effectiveness of the drug and the safety of patients. The dosage of many drugs varies depending on the patient's age. However, as our understanding of human biology deepens, we believe that these instructions need to be modified to incorporate different life stages. This is because human biology and metabolism differ significantly among different life stages, and their responses to drugs also vary. Additionally, the same age of different persons may fall into different life stages. Therefore, our group from multiple institutes and countries proposes a reexamination of whether incorporating life stages in all or any drug instructions will greatly enhance drug efficiency and patients' health.

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KW - Life stage

KW - Metabolism

KW - Puberty

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A Perspective on Evaluating Life Stage Differences in Drug Dosages for Drug Labeling and Instructions

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Keywords

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