@inproceedings{9c51ae4325c443af932ed8f44d73c890,
title = "A Low Noise Current Readout with 124 dB Dynamic Range for Bioluminescence Sensing",
abstract = "This paper presents a lower-power photocurrent measurement system for biomolecule quantification. The designed readout comprises a proposed capacitive feedback transimpedance amplifier (C-TIA) in conjunction with an asynchronous flip switch and a self-timed reset network followed by a reconfigurable time-domain quantization scheme. Unlike conventional C-TIAs, this readout provides frequency output without requiring an external clock to perform a periodic reset. Fabricated in a standard 180 nm CMOS process, the readout achieves a current measurement range of 124 dB spanning from 2 pA ∼ 3.5 μ A, a 98.3\% linearity, and a 1 pArms input-referred noise, while consuming only 378 μ W. In vitro NanoLuc (NLuc) luciferase-based bioluminescence sensing for biomolecule quantification is demonstrated using this chip.",
keywords = "Bioluminescence sensing, Current readout, Low noise, Wide dynamic range",
author = "Awan, \{Muhammad Asfandyar\} and Samar Shurbaji and Amine Bermak and Biswas, \{Kabir H.\} and Bo Wang",
note = "Publisher Copyright: {\textcopyright} 2024 IEEE.; 2024 IEEE Biomedical Circuits and Systems Conference, BioCAS 2024 ; Conference date: 24-10-2024 Through 26-10-2024",
year = "2024",
month = oct,
day = "26",
doi = "10.1109/BioCAS61083.2024.10798344",
language = "English",
series = "2024 IEEE Biomedical Circuits and Systems Conference, BioCAS 2024",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
booktitle = "2024 IEEE Biomedical Circuits and Systems Conference, BioCAS 2024",
address = "United States",
}