A clone contig of 12q24.3 Encompassing the distal hereditary motor neuropathy type II gene

Joy Irobi; Fadel Tissir; Peter De Jonghe; Els De Vriendt; Christine Van Broeckhoven; Vincent Timmerman; Joke Beuten

doi:10.1006/geno.2000.6149

A clone contig of 12q24.3 Encompassing the distal hereditary motor neuropathy type II gene

Joy Irobi, Fadel Tissir, Peter De Jonghe, Els De Vriendt, Christine Van Broeckhoven, Vincent Timmerman, Joke Beuten^*

^*Corresponding author for this work

Flanders Institute for Biotechnology

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

We previously assigned the disease locus for autosomal dominant hereditary motor neuropathy type II (distal HMN II) within a 13-cM interval at chromosome 12q24.3. We constructed a physical map of the distal HMN II region based on yeast artificial chromosomes (YACs), P1 artificial chromosomes (PACs), and bacterial artificial chromosomes (BACs) using an STS content mapping approach. The contig contains 26 YAC, 15 PAC, and 60 BAC clones and covers a physical distance of approximately 5 Mb. A total of 99 STS markers, including 25 known STSs and STRs, 49 new STSs generated from clone end-fragments, 20 ESTs, and 5 known genes, were located on the contig. This physical map provides a valuable resource for mapping genes and markers located within the distal HMN II region and facilitates the positional cloning of the distal HMN II gene. (C) 2000 Academic Press.

Original language	English
Pages (from-to)	34-43
Number of pages	10
Journal	Genomics
Volume	65
Issue number	1
DOIs	https://doi.org/10.1006/geno.2000.6149
Publication status	Published - 1 Apr 2000
Externally published	Yes

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title = "A clone contig of 12q24.3 Encompassing the distal hereditary motor neuropathy type II gene",

abstract = "We previously assigned the disease locus for autosomal dominant hereditary motor neuropathy type II (distal HMN II) within a 13-cM interval at chromosome 12q24.3. We constructed a physical map of the distal HMN II region based on yeast artificial chromosomes (YACs), P1 artificial chromosomes (PACs), and bacterial artificial chromosomes (BACs) using an STS content mapping approach. The contig contains 26 YAC, 15 PAC, and 60 BAC clones and covers a physical distance of approximately 5 Mb. A total of 99 STS markers, including 25 known STSs and STRs, 49 new STSs generated from clone end-fragments, 20 ESTs, and 5 known genes, were located on the contig. This physical map provides a valuable resource for mapping genes and markers located within the distal HMN II region and facilitates the positional cloning of the distal HMN II gene. (C) 2000 Academic Press.",

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T1 - A clone contig of 12q24.3 Encompassing the distal hereditary motor neuropathy type II gene

AU - Irobi, Joy

AU - Tissir, Fadel

AU - De Jonghe, Peter

AU - De Vriendt, Els

AU - Van Broeckhoven, Christine

AU - Timmerman, Vincent

AU - Beuten, Joke

PY - 2000/4/1

Y1 - 2000/4/1

N2 - We previously assigned the disease locus for autosomal dominant hereditary motor neuropathy type II (distal HMN II) within a 13-cM interval at chromosome 12q24.3. We constructed a physical map of the distal HMN II region based on yeast artificial chromosomes (YACs), P1 artificial chromosomes (PACs), and bacterial artificial chromosomes (BACs) using an STS content mapping approach. The contig contains 26 YAC, 15 PAC, and 60 BAC clones and covers a physical distance of approximately 5 Mb. A total of 99 STS markers, including 25 known STSs and STRs, 49 new STSs generated from clone end-fragments, 20 ESTs, and 5 known genes, were located on the contig. This physical map provides a valuable resource for mapping genes and markers located within the distal HMN II region and facilitates the positional cloning of the distal HMN II gene. (C) 2000 Academic Press.

AB - We previously assigned the disease locus for autosomal dominant hereditary motor neuropathy type II (distal HMN II) within a 13-cM interval at chromosome 12q24.3. We constructed a physical map of the distal HMN II region based on yeast artificial chromosomes (YACs), P1 artificial chromosomes (PACs), and bacterial artificial chromosomes (BACs) using an STS content mapping approach. The contig contains 26 YAC, 15 PAC, and 60 BAC clones and covers a physical distance of approximately 5 Mb. A total of 99 STS markers, including 25 known STSs and STRs, 49 new STSs generated from clone end-fragments, 20 ESTs, and 5 known genes, were located on the contig. This physical map provides a valuable resource for mapping genes and markers located within the distal HMN II region and facilitates the positional cloning of the distal HMN II gene. (C) 2000 Academic Press.

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A clone contig of 12q24.3 Encompassing the distal hereditary motor neuropathy type II gene

Abstract

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