Projects per year
Personal profile
Biography
Dr. Mohammed R. Shaker is a Scientist at the Neurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI) at Hamad Bin Khalifa University. He earned his PhD in Neuroscience from Korea University, Seoul, in 2017, and was subsequently awarded the prestigious Brain Korea 21 Plus Fellowship. He then joined the Australian Institute for Bioengineering & Nanotechnology (AIBN) at The University of Queensland, where he advanced organoid models for the study of human brain and spinal cord development.
Dr. Shaker’s research integrates patient-derived induced pluripotent stem cells (iPSCs) with organoid platforms, focusing on neurological disorders, e.g. white matter diseases and neural tube defects. His work has garnered multiple national and international accolades, such as fellowships from the Children’s Hospital Foundation and the European Leukodystrophy Association. Dr. Shaker continues to explore innovative 3D culture systems and computational approaches to accelerate breakthroughs in neuroregeneration and disease modeling. His pioneering research remains at the forefront of precision medicine and translational neuroscience.
Education/Academic qualification
Neuroscience, PhD, Korea University
1 Sept 2013 → 28 Feb 2017
Award Date: 28 Feb 2017
Developmental Neurobiology, Master, University of Malaya (Malaysia)
1 Sept 2011 → 31 Jul 2013
Award Date: 31 Jul 2013
Biomedical Science , Bachelor, University of Malaya
1 Jul 2007 → 31 Dec 2010
Award Date: 31 Dec 2010
External positions
Research Fellow, The University of Queensland
12 Nov 2018 → 30 Nov 2024
Research Professor, Korea University
1 Mar 2017 → 9 Nov 2018
Keywords
- RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
- Stem Cells
- Autism spectrum disorder
- Developmental Neuroscience
- White matter diseases
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Collaborations and top research areas from the last five years
Projects
- 3 Active
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HBKU-OVPR-TG-03-39: A Technology to Model Brain Neural Tube Folding in vitro for Precision Medicine
Al-Maslamani, N. A. A. A. (Lead Principal Investigator), Zekri, A. (Principal Investigator), Schneider, J. (Principal Investigator) & Shaker, M. (Principal Investigator)
1/11/25 → 31/10/27
Project: Experimental Development/Translation Research
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HBKU-OVPR-SRG-03-2: A cell line multi-omics AI based approach to screen for the effects of a Qatari RGS4 gene mutation on G protein stabilization in Autism
Bensmail, H. (Co-Lead Principal Investigator), Abdesselem, H. B. (Principal Investigator), Ouararhni, K. (Principal Investigator), El Hajj, N. (Co-Lead Principal Investigator), Park, Y. (Principal Investigator), Katanaev, V. (Co-Lead Principal Investigator), Hottenga, J. J. (Lead Principal Investigator) & Shaker, M. (Principal Investigator)
10/07/25 → 9/07/27
Project: Experimental Development/Translation Research
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QBRI-CORE-000018: Stem Cell Technology for Neurodevelopmental and Neurological Disorders
Shaker, M. (Lead Principal Investigator) & Taha, R. Z. S. (Post Doctoral Fellow)
1/01/25 → 31/12/27
Project: Experimental Development/Translation Research
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Enhanced U-Net-Based Deep Learning Model for Automated Segmentation of Organoid Images
Alani, M., Jalab, H. A., Pars, S., Al-mhanawi, B., Taha, R. Z., Wolvetang, E. J. & Shaker, M. R., 7 Nov 2025, In: Bioengineering. 12, 11, 12 p., 1216.Research output: Contribution to journal › Article › peer-review
Open Access -
Klotho overexpression protects human cortical neurons from β-amyloid induced neuronal toxicity
Shaker, M. R., Salloum-Asfar, S., Taha, R. Z., Javed, I. & Wolvetang, E. J., 28 Mar 2025, In: Molecular Brain. 18, 1, 27.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
SARS-CoV-2 infection in hiPSC-derived neurons is cathepsin-dependent and causes differential accumulation of HIF1ɑ and phosphorylated tau
Kettunen, P., Ruuska, J., Quirin, T., Ojha, R., Saber, S. H., Sng, J. D. J., Morrison, S., Al-Mhanawi, B., Shaker, M. R., De Neck, S., Kipar, A., Paavolainen, L., Wolvetang, E., Joensuu, M., Koistinaho, J., Rolova, T. & Balistreri, G., 9 Dec 2025, In: Molecular Therapy Nucleic Acids. 36, 4, 102726.Research output: Contribution to journal › Article › peer-review
Open Access -
Valproic acid-induced teratogenicity is driven by senescence and prevented by Rapamycin in human spinal cord and animal models
Pietrogrande, G., Shaker, M. R., Stednitz, S. J., Soheilmoghaddam, F., Aguado, J., Morrison, S. D., Zambrano, S., Tabassum, T., Javed, I., Cooper-White, J., Davis, T. P., O’Brien, T. J., Scott, E. K. & Wolvetang, E. J., Mar 2025, In: Molecular Psychiatry. 30, 3, p. 986-998 13 p., 200.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
A Roadmap for Selecting and Utilizing Optimal Features in scRNA Sequencing Data Analysis for Stem Cell Research: A Comprehensive Review
Alani, M., Altarturih, H., Pars, S., Al-mhanawi, B., Wolvetang, E. J. & Shaker, M. R., 30 Nov 2024, In: International Journal of Stem Cells. 17, 4, p. 347-362 16 p.Research output: Contribution to journal › Review article › peer-review
Open Access2 Citations (Scopus)