Personal profile
Biography
Maha Al-Thani is a Research Fellow at Qatar Biomedical Research Institute, specializing in human iPSC disease modeling and neurovascular co-cultures. She earned her PhD in Clinical Neurosciences from the University of Cambridge, where her dissertation focused on developing novel hiPSC-derived models for cerebral small vessel disease (COL4A1/2 and HTRA1 variants). This groundbreaking work, which was later used in a drug-screening collaboration with AstraZeneca, was funded by a consortium of leading UK research foundations. In her current research, she is applying this expertise to model the blood-brain barrier in Autism Spectrum Disorder (ASD), aiming to uncover its role in the neurobiology of autism.
Education/Academic qualification
Clinical Neuroscience, PhD, hiPSC-DERIVED CEREBRAL SMALL VESSEL DISEASE MODELS , University of Cambridge
Oct 2019 → May 2023
Award Date: 20 Jul 2024
Biological & Biomedical Sciences, Master, EXPLORE THE ROLE OF C-TERMINALLY TRUNCATED ALPHA-SYNUCLEIN IN PARKINSON'S DISEASE AND DEMENTIA WITH LEWY BODIES PATHOGENESIS, Hamad Bin Khalifa University
Sept 2017 → Jun 2019
Award Date: 1 Jun 2019
Biomedical Science, Bachelor, Qatar University
Sept 2009 → Jun 2015
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Collaborations and top research areas from the last five years
Research output
- 4 Article
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In vitro platform to model the function of ionocytes in the human airway epithelium
Vilà-González, M., Pinte, L., Fradique, R., Causa, E., Kool, H., Rodrat, M., Morell, C. M., Al-Thani, M., Porter, L., Guo, W., Maeshima, R., Hart, S. L., McCaughan, F., Granata, A., Sheppard, D. N., Floto, R. A., Rawlins, E. L., Cicuta, P. & Vallier, L., 25 Apr 2024, In: Respiratory Research. 25, 1, 13 p., 180.Research output: Contribution to journal › Article › peer-review
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A novel human iPSC model of COL4A1/A2 small vessel disease unveils a key pathogenic role of matrix metalloproteinases
Al-Thani, M., Goodwin-Trotman, M., Bell, S., Patel, K., Fleming, L. K., Vilain, C., Abramowicz, M., Allan, S. M., Wang, T., Cader, M. Z., Horsburgh, K., Van Agtmael, T., Sinha, S., Markus, H. S. & Granata, A., 12 Dec 2023, In: Stem Cell Reports. 18, 12, p. 2386-2399 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Association of Vascular Risk Factors and Genetic Factors With Penetrance of Variants Causing Monogenic Stroke
Cho, B. P. H., Harshfield, E. L. & Al-Thani, M., 1 Dec 2022, In: JAMA Neurology. 79, 12, p. 1303-1311 9 p.Research output: Contribution to journal › Article › peer-review
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Glycine improves peritoneal vasoreactivity to dialysis solutions in the elderly
Zakaria, E. R., Joseph, B., Hamidi, M., Zeeshan, M., Algamal, A., Sartaj, F., Althani, M., Fadl, T. & Madan, D., 23 Jan 2020, In: Qatar Medical Journal. 2019, 3, A74.Research output: Contribution to journal › Article › peer-review